Research Interests:

The laboratory works in the field of systems biology the objective of which is the study of biological systems, including genes, RNAs, proteins, metabolites and cells in a focused manner, and organs, organisms and populations in a broader context.


Areas of research focus include:

  • Studying the effects of man-made contaminants (e.g. microplastics, persistent organic pollutants, xenobiotics) on marine and human health

  • Studying prostate cancer in the context of racial differences and nutritional deficiency

  • Examining the impacts of long term space travel – specifically the effects of nutrition, torpor, space radiation and microgravity on hepatic and intestinal biology

  • Developing a rat model of opioid abuse to better understand the biological basis for substance abuse disorders and advance development of preventive strategies and more efficacious treatments

  • Developing a robust toolkit for better integration of Omics data sets into genotype-phenotype predictions.

  • Studying the role of noncoding RNAs in the development of cancer and metabolic diseases




Teaching

Current Teaching

Module Code Module Title
BIO2302 Food Choice, Diet and Health
BIO3301 Food Supply Safety Chain & Security
BIO4102 & ALU8002 Advanced Food Bioanalysis
BIO2305 Molecular Genetics and Bioinformatics
SCM8152 Systems Medicine: From Molecules to Populations

Supervise students and/or dissertation marking from the following courses

Module Code Course Title
BIO3308 4th Honors Project
BIO4301 MSci Research Project
BBC8003 MSc Molecular Biology & Biotechnology Research Project
BIO3302 FQN Honours Project Module

Past Teaching at Medical University of South Carolina, SC

Role Faculty Module Code Module Title
Faculty College of Graduate Studies CGS 727 Designing Rigorous Research; Principles in Rigor, Transparency and Reproducibility
Faculty College of Graduate Studies CGS 780 Human Genetics & Genomics

Guest Lecturer at Medical University of South Carolina, SC

Departments
Pathology, Pediatrics, Pulmonary, Critical Care, Allergy & Sleep Medicine, and Public Health Sciences

Past Teaching at University of California San Diego/San Diego State University, CA

Role Module Code Module Title
Course Co-Director FPM237 Microarray Genomics Technology and Informatics
Lecturer MED260 Modern Techniques of Biomedical Research
Course Director BIOL-40050 From Gene to Function
Course Director BIOL-40127 Microarray Technologies
Lecturer BIOM-200B From the Molecule to the Organism
Lecturer BIOM-252 Human Genetics and Genomics

Meet the Team

The Hardiman Lab is based in the School of Biological Sciences and the Institute for Global food Security at Queen’s University Belfast

Principal Investigator

Researchers

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Adam Harris

Running, cycling, rowing, All things data and computers

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Alix McDaid

Surfing, skating, playing piano, Microplastics

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Christina Biamis

Travelling, Science, Art and Food, Microplastics

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Dr Willian Abraham da Silveira PhD

Travelling, Reading, Martial Arts, History, Philosophy, Multi-omics, Ageing and space travel

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Hao Wang

Travelling, Running, Playing the flute, Metabolic diseases, miRNAs and lncRNAs

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James Mackle

IOT, Woodwork, Guitar, Piano, Addiction, Multi-omics, Machine Learning

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Rebecca Morgan

Animal welfare, Classical Piano, Prostate cancer, lncRNAs, Vitamin D, Fusion genes

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Thomas Cahill

Keeping active, Science, Irish language culture and history, Current affairs, Travelling, Torpor, Mental health, Cancer research

Students

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Conor Porter

Reading, Guitar, Spending time with my friends and family, Smoltification of Atlantic salmon

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Heather Greig

Live music, Travelling, Cooking, Walking my dogs, Learning Irish, Hibernation and Space Flight

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Richard Hillis

Swimming, Baking, Guitar, Painting, Drawing, Art, Travelling, Languages, Reading, Sci-fi, Hibernation and Space Flight

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Ryan Millar

Sport, Travelling, Scuba Diving, Reading, Cancer Biology

Lab Alumni:

Name Role Year
Madison Brown MSc Bioinformatics and Computational Genomics 2020
Jacopo Umberto Verga MSc Molecular and Applied Biology (Università Politecnica delle Marche, Italy) ERASMUS Programme 2020
Dulcie Keeley BSc Biological Sciences 2020
Diarmuid Owens BSc Biological Sciences 2020
Keir Herink BSc Biological Sciences 2020
Amirah Mohamud MSc Molecular Biology & Biotechnology 2019
Zehao Chen MSc Molecular Biology & Biotechnology 2019

Partners and Collaborators

I maintain active research collaborations with groups in the USA (University of California, Medical University of South Carolina, Wake Forest School of Medicine), (Université de Camerino & Università Politecnica delle Marche (Italy), National University of Ireland Galway (Ireland), University of Aberdeen (Scotland) and Swansea University (Wales).

Funding

Current and Recent Research Funding

Title Role Funder
Development of a biopsychosocial translational research programme in post-traumatic stress disorder co-I UKRI/ESRC
Actions of endocrine disrupting chemicals in seabirds Supervisor UKRI/NERC
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model MPI US NIH/NIDA
Medical University of South Carolina Transdisciplinary Collaborative Center in Precision Medicine and Minority Men’s Health Subcontract PI NIH/NIMHD
Effect of Induced Hibernation and Prolonged Radiation Exposure on the Zebrafish Gut Epigenome PI NASA/SC-EPSCoR USA
Statistical Methods for Genetic Studies, Using Network and Integrative Analysis Co-I US NIH/NIGMS
A Novel Multiscale Data Integration Framework for Omics Big Data Modeling (in the Genomes to Phenomes framework) PI NSF/SC-EPSCOR Pilot
Algorithms for Literature-Guided Multi-Platform Identification of Cancer Subtypes Co-I US NIH/NCI

Presentations

Microplastics


Christina Biamis - Microplastic-derived Endocrine Disrupting Chemicals on Seabird Epigenetics Video Presentation



Alix McDaid - Investigating the emerging issue of microplastics and their impact on terrestrial ecosystems

Torpor


Thomas Cahill - Utilization of an induced torpor-like state as a countermeasure for low dose radiation exposure in a zebrafish model

Software

miRmapper

miRmapper is an R package for analyzing the predicted impact that micro RNAs have on the post transcriptional regulation of mRNAs. The user will provide the list of miRNAs of interest and the predicted target genes for each, as well as a list of the differentially expressed genes from the sequencing experiment. miRmapper will generate metrics and plots of the interactions.

PIMENTo

PIMENTo is an R package to normalize, analyze, and visualize microarray data

Research In The News



Scientists examine why travelling through space, exposure to radiation and micro-gravity ‘accelerate ageing’



Simulated heart attacks could help researchers screen drugs



Fabulous scientific facts - as chosen by scientists; Zebrafish could help humans reach Mars



Interplay Between MicroRNAs and Targeted Genes in Cellular Homeostasis of Adult Zebrafish (Danio rerio)



Gary Hardiman (Medical University of South Carolina) received U01 to study opioid dependence in HS rats



Guardians of the environment



Hollings Cancer Center researcher lands $8M grant to improve cancer outcomes for minority men



Racial Disparities At Transcriptome Level Found For Prostate Cancer



Prostate Cancer Genes in African American Men May Be Affected by Vitamin D Supplementation



Transcriptome differences in prostate cancer highlight racial disparities and vitamin D



Weathered oil from DW Horizon spill may threaten fish embryos and larvae development





Harnessing Big Data





Split Decision: Stem Cell Signal Linked With Cancer Growth



Researchers Describe First Functioning “Lipidome” of Mouse Macrophage



Q&A: UCSD’s Hardiman on an Aquatic Multispecies Array to Study the Effects of Endocrine Disruption



UC San Diego Receives $2.5 Million NIH Grant To Establish Digestive Diseases Research Center



UCSD’s Gary Hardiman Discusses The Future Of Core Array Faclities



Contact

  • +44 (0)28 9097 4961
  • 19 Chlorine Gardens, Belfast, Antrim BT9 5DL
  • Institute for Global Food Security: Biological Sciences Building
  • Monday - Friday 09:00 to 17:00